Glandex works from the inside out. The patented formula uses a unique fiber blend to promote bulky, firm stools, which apply natural pressure to the anal glands during defecation and help them empty on their own. The formula also contains omega fatty acids to support a healthy inflammatory response and maintain normal histamine levels, plus probiotics and digestive enzymes to support GI health. A healthy digestive tract directly supports healthy anal gland function — the two systems work together.